Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.371


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU5F1chr6_-_311346140.591.7e-02Click!
SOX2chr3_+_181429711-0.273.1e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_216241321 15.620 FN1
fibronectin 1
chr10_+_7745229 5.966 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745325 5.804 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745284 5.663 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_+_133494275 5.633 TF
transferrin
chr17_+_27370155 5.380 PIPOX
pipecolic acid oxidase
chr10_+_7745354 5.312 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_100495972 4.866 MTTP
microsomal triglyceride transfer protein
chr4_-_187644983 4.575 NM_005245
FAT1
FAT tumor suppressor homolog 1 (Drosophila)
chr17_+_27369917 4.568 NM_016518
PIPOX
pipecolic acid oxidase
chr11_+_69455938 3.919 CCND1
cyclin D1
chr16_-_55867016 3.734 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr10_+_5005685 3.515 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr10_-_5045967 3.403 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr4_-_15940362 3.080 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr11_+_69455837 3.078 NM_053056
CCND1
cyclin D1
chr8_-_17752847 2.950 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr10_+_5005601 2.798 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_5005453 2.761 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr7_+_94292816 2.727 PEG10
paternally expressed 10
chr17_-_64225496 2.680 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr13_-_48987017 2.611 LPAR6
lysophosphatidic acid receptor 6
chr15_+_25068793 2.489 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr15_+_25101697 2.473 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr2_-_21225640 2.389 APOB
apolipoprotein B (including Ag(x) antigen)
chr10_+_124151818 2.363 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr5_+_76114832 2.313 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr7_+_94292737 2.269 PEG10
paternally expressed 10
chr16_+_72088507 2.263 NM_001126102
NM_005143
HP

haptoglobin

chr4_-_110723334 2.200 NM_000204
CFI
complement factor I
chr20_-_6104056 2.193 NM_017671
FERMT1
fermitin family member 1
chr2_+_138721807 2.183 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr4_+_74281884 2.106 ALB
albumin
chr10_-_52645430 2.106 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr11_+_69455978 2.096 CCND1
cyclin D1
chr10_+_123754141 2.072 TACC2
transforming, acidic coiled-coil containing protein 2
chr13_+_97794050 1.852 MBNL2
muscleblind-like 2 (Drosophila)
chr19_-_48389514 1.794 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr5_+_76114881 1.627 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr12_-_123187842 1.595 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr4_+_140586921 1.515 NM_001204366
NM_001204367
NM_001204368
NM_002413
MGST2



microsomal glutathione S-transferase 2



chr7_+_29519485 1.434 NM_001039936
CHN2
chimerin (chimaerin) 2
chr10_+_7745341 1.427 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_114133775 1.425 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_148939784 1.421 NM_000096
CP
ceruloplasmin (ferroxidase)
chr9_-_75567915 1.408 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr2_+_113885137 1.388 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr12_-_123201319 1.357 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr6_-_47254143 1.351 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr11_-_2152960 1.313 IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_-_149095413 1.303 TM4SF1
transmembrane 4 L six family member 1
chr10_+_123923104 1.282 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr11_+_69455884 1.247 CCND1
cyclin D1
chr6_+_64286348 1.202 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_+_113885145 1.169 IL1RN
interleukin 1 receptor antagonist
chr17_-_48945338 1.153 NM_001243877
TOB1
transducer of ERBB2, 1
chr13_-_45048436 1.149 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr3_-_56809594 1.109 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr2_+_211458078 1.105 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr5_+_59784004 1.091 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr10_+_114133838 1.048 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr18_+_61420276 1.047 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr9_+_97521930 1.031 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr3_-_9920633 1.003 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr11_-_35441501 0.961 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr16_+_15031299 0.953 NM_006985
NPIP
nuclear pore complex interacting protein
chr3_+_100238063 0.939 TMEM45A
transmembrane protein 45A
chr4_+_140587086 0.899 MGST2
microsomal glutathione S-transferase 2
chr4_-_155511838 0.899 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr5_-_95158365 0.891 GLRX
glutaredoxin (thioltransferase)
chr5_-_95158465 0.863 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chrY_-_2655478 0.859 NM_003140
SRY
sex determining region Y
chr18_+_29171729 0.854 NM_000371
TTR
transthyretin
chr3_+_12392993 0.852 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr2_+_228678556 0.838 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr10_-_29923900 0.830 NM_021738
SVIL
supervillin
chr5_+_125758818 0.812 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr12_+_100897137 0.808 NM_001206992
NM_001206993
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr4_+_74301932 0.808 NM_001134
AFP
alpha-fetoprotein
chr5_+_176516550 0.805 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr18_-_3011944 0.796 NM_014646
LPIN2
lipin 2
chr9_-_104145800 0.783 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr2_+_128928040 0.774 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr1_+_81771844 0.754 LPHN2
latrophilin 2
chr9_+_97488993 0.739 C9orf3
chromosome 9 open reading frame 3
chr10_-_116418056 0.726 NM_002313
ABLIM1
actin binding LIM protein 1
chr2_-_219157207 0.718 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr3_+_46619075 0.694 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr12_-_6484389 0.691 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_-_170744767 0.662 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr7_-_55930444 0.653 NM_207366
SEPT14
septin 14
chr1_+_32050510 0.631 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr4_+_187187342 0.629 F11
coagulation factor XI
chr18_-_28622624 0.626 NM_001941
NM_024423
DSC3

desmocollin 3

chr9_-_21350885 0.608 NM_021002
IFNA6
interferon, alpha 6
chr6_-_138820580 0.591


chr4_+_187187117 0.578 NM_000128
F11
coagulation factor XI
chr12_+_133757994 0.573 NM_001165883
NM_001165884
NM_001165885
NM_001165886
NM_001165887
NM_003415
NM_152943
NM_001165881
NM_001165882
ZNF268








zinc finger protein 268








chr1_+_57320442 0.571 NM_000562
C8A
complement component 8, alpha polypeptide
chr2_-_97405799 0.566 NM_001142292
NM_030805
LMAN2L

lectin, mannose-binding 2-like

chr7_+_47694841 0.559 NM_001123065
C7orf65
chromosome 7 open reading frame 65
chr10_-_98325100 0.554 TM9SF3
transmembrane 9 superfamily member 3
chr9_-_112191105 0.553 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr21_-_27253197 0.552 APP
amyloid beta (A4) precursor protein
chr4_-_186578122 0.549 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr1_+_205473683 0.549 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr3_-_123603144 0.548 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr7_+_1126442 0.538 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr17_-_79105747 0.523 NM_004920
AATK
apoptosis-associated tyrosine kinase
chr17_+_53342356 0.520 HLF
hepatic leukemia factor
chrX_+_2958274 0.514 NM_001201538
ARSF
arylsulfatase F
chr11_-_18258315 0.512 SAA4
serum amyloid A4, constitutive
chr7_+_37723378 0.512


chrX_-_10535476 0.511 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr17_-_46608271 0.507 NM_002144
HOXB1
homeobox B1
chr10_-_29754478 0.505 SVIL
supervillin
chr11_+_131240370 0.502 NM_001048209
NTM
neurotrimin
chr12_-_14996381 0.498 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr15_+_59904090 0.495 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr10_-_73848766 0.490 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr10_+_123922940 0.482 TACC2
transforming, acidic coiled-coil containing protein 2
chr14_-_95608054 0.477 NM_030621
DICER1
dicer 1, ribonuclease type III
chr2_+_234600320 0.462 NM_205862
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr6_+_131894343 0.453 NM_000045
NM_001244438
ARG1

arginase, liver

chr18_-_61329113 0.449 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chrX_-_106362050 0.447 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr4_-_186733372 0.434 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr1_-_160492982 0.424 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr10_-_69597768 0.423 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr19_+_58513428 0.421 LOC100128398
uncharacterized LOC100128398
chr15_-_77154284 0.420 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr12_-_11091805 0.417 NM_023922
TAS2R14
taste receptor, type 2, member 14
chr5_+_125759076 0.408 GRAMD3
GRAM domain containing 3
chr4_+_154178525 0.394 TRIM2
tripartite motif containing 2
chr4_+_70796798 0.388 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr20_-_45927496 0.385 ZMYND8
zinc finger, MYND-type containing 8
chr2_-_188419185 0.372 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr1_+_167298382 0.371 POU2F1
POU class 2 homeobox 1
chr4_+_184020343 0.370 NM_024949
WWC2
WW and C2 domain containing 2
chr7_-_29186072 0.363 NM_019029
NM_031311
CPVL

carboxypeptidase, vitellogenic-like

chr18_-_21891469 0.362 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr3_+_156008775 0.358 NM_172159
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr4_-_70361578 0.350 NM_021139
UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
chr6_+_64356430 0.339 NM_015153
PHF3
PHD finger protein 3
chr10_-_123356158 0.336 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr20_+_32951054 0.336 NM_031483
ITCH
itchy E3 ubiquitin protein ligase homolog (mouse)
chr5_+_140739589 0.332 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr14_+_39649711 0.329 PNN
pinin, desmosome associated protein
chr16_+_10522724 0.323 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr2_-_161056573 0.321 NM_000888
ITGB6
integrin, beta 6
chr9_+_79968344 0.317 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr10_+_101542460 0.316 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr14_+_69658193 0.314 NM_001193360
NM_001193361
NM_018199
EXD2


exonuclease 3'-5' domain containing 2


chr14_+_69658215 0.309 EXD2
exonuclease 3'-5' domain containing 2
chr14_-_24423329 0.307 C14orf167
chromosome 14 open reading frame 167
chr20_+_57470200 0.307 GNAS
GNAS complex locus
chr9_+_124048396 0.305 GSN
gelsolin
chr12_-_28124915 0.299 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr2_-_188419049 0.298 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr19_-_57678855 0.293 NM_001012729
DUXA
double homeobox A
chr10_-_42863435 0.292 LOC441666
zinc finger protein 91 pseudogene
chr3_+_148447966 0.291 NM_032049
AGTR1
angiotensin II receptor, type 1
chr10_-_97200895 0.276 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr12_+_64803741 0.275 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr2_-_161056762 0.274 ITGB6
integrin, beta 6
chr16_-_21314371 0.271 NM_001014444
NM_001888
CRYM

crystallin, mu

chr6_+_167525294 0.270 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr21_-_43346780 0.268 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr12_+_21168629 0.267 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr19_+_47421932 0.264 NM_004491
ARHGAP35
Rho GTPase activating protein 35
chr7_-_87342569 0.260 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr15_-_83474805 0.259 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr3_-_194072004 0.255 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr1_+_28764660 0.253 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr18_+_29027731 0.251 NM_001944
DSG3
desmoglein 3
chr12_-_498428 0.251 NM_001042603
KDM5A
lysine (K)-specific demethylase 5A
chr7_+_26400503 0.250 NM_001199837
SNX10
sorting nexin 10
chr14_+_23789396 0.248 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr8_+_92114846 0.247 NM_001129890
LRRC69
leucine rich repeat containing 69
chr8_+_32579350 0.245 NM_001159996
NRG1
neuregulin 1
chr1_-_41625539 0.244 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr1_+_110546569 0.241 NM_001242675
NM_001242676
AHCYL1

adenosylhomocysteinase-like 1

chr3_-_47933997 0.241 MAP4
microtubule-associated protein 4
chr1_-_150947456 0.240 NM_022075
NM_181746
CERS2

ceramide synthase 2

chr1_+_16083132 0.238 FBLIM1
filamin binding LIM protein 1
chr18_+_46065367 0.236 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chrX_+_100474932 0.234 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr22_+_35695267 0.231 NM_001135729
TOM1
target of myb1 (chicken)
chr19_-_5838740 0.229 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr13_+_76194569 0.225 NM_005358
LMO7
LIM domain 7
chr12_-_8815370 0.219 NM_003480
MFAP5
microfibrillar associated protein 5
chr22_+_18043147 0.216 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr1_+_112938799 0.213 NM_018704
CTTNBP2NL
CTTNBP2 N-terminal like
chr7_+_20686965 0.211 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr9_-_36375965 0.206 RNF38
ring finger protein 38
chr11_-_112034671 0.201 NM_001243211
NM_001562
IL18

interleukin 18 (interferon-gamma-inducing factor)

chr19_-_5839702 0.198 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr17_+_61851557 0.191 NM_007372
NM_203499
DDX42

DEAD (Asp-Glu-Ala-Asp) box polypeptide 42

chr20_+_19915716 0.190 RIN2
Ras and Rab interactor 2
chr2_+_204801453 0.187 NM_012092
ICOS
inducible T-cell co-stimulator

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.21 6.16e-05 GO:0006629 lipid metabolic process
8.39 1.34e-03 GO:0032787 monocarboxylic acid metabolic process
5.27 4.58e-03 GO:0044255 cellular lipid metabolic process
22.47 9.88e-03 GO:0006690 icosanoid metabolic process
21.17 1.25e-02 GO:0033559 unsaturated fatty acid metabolic process
18.35 2.21e-02 GO:0006641 triglyceride metabolic process
17.21 2.85e-02 GO:0006638 neutral lipid metabolic process
17.21 2.85e-02 GO:0006639 acylglycerol metabolic process
7.92 3.42e-02 GO:0008202 steroid metabolic process
10.52 3.65e-02 GO:0006869 lipid transport

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.16 9.51e-03 GO:0005615 extracellular space

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
274.98 3.58e-06 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
206.24 1.43e-05 GO:0047023 androsterone dehydrogenase activity
6.86 3.67e-04 GO:0008289 lipid binding
274.98 1.04e-03 GO:0047026 androsterone dehydrogenase (A-specific) activity
274.98 1.04e-03 GO:0047718 indanol dehydrogenase activity
39.30 4.54e-03 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
37.52 5.25e-03 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
31.75 8.77e-03 GO:0016229 steroid dehydrogenase activity
110.00 1.04e-02 GO:0032052 bile acid binding
11.24 3.38e-02 GO:0008201 heparin binding